In December or 2020, there were a few reports of patients developing transient facial and lip swelling in patients who have received a dose of the Moderna vaccine. All of these patients had previously received hyaluronic acid (HA) fillers. These reactions all resolved quickly and similar reactions have been reported with other COVID-19 vaccines and with other types of vaccinations as well.

In March of 2021, the Canadian Dermatology Association (CDA) issued recommendations regarding COVID-19 vaccinations and hyaluronic acid (HA) dermal filler use.

They recommended:

• The benefits of vaccination far outweigh the possible but extremely rare risks of vaccine-related filler reactions and should not dissuade someone from receiving the vaccine.
• Patients who have received hyaluronic acid dermal fillers in the past may get a COVID-19 vaccination if they so desire.
• If a patient has received a COVID-19 vaccine in the past, they can receive hyaluronic acid dermal fillers in the future.
• It may be preferable to wait two weeks after HA dermal fillers before being vaccinated BUT if the opportunity arises to receive a vaccine earlier, then the patient should consider receiving the vaccine regardless.
• It may be preferable to wait two weeks after a COVID-19 vaccine before receiving a HA dermal filler.